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Play a fun falling-block tile-matching video game with Mario and his friends in this fun remake of the classic game - Dr. Mario 64!

Dr. Mario 64 is a tile-matching action puzzle game featuring the beloved character Mario. Initially released back in 2001 for the Nintendo 64, Dr. Mario 64 is an enhanced remake of the classic 1990 video game Dr. Mario. Help Mario defeat various bacterias and viruses by matching a variety of medicinal drugs and pills. Choose and play one of the several single-player modes and have fun.

Emulator Controls

= Directions

 enter  = Start

J = A   K = B

W A S D = Joystick

Q = L   E = R

  space   = Z

U I L O = C-buttons

How to Save Game

Related Games

Dr. Mario 64 is an online N64 game that you can play at Emulator Online. This free Nintendo 64 game is the United States of America region version for the USA. Dr. Mario 64 is a single title from the many puzzle games, arcade games and mario games offered for this console. If you enjoyed playing this, then you can find similar games in the n64 games category. Dr. Mario 64 game is from the various retro games on the site, and there are more games like this, including Tetris & Dr. Mario, Super Mario 64 and Dr. Mario.